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Custom Synthesis

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Global  Chemsources represents a number of clients who offer production capacity and technological skills to carry out contract manufacturing of sophisticated organic chemical products on a custom basis.  Included in their clients' strengths are the following offerings:

 

Core Competency

Reagent / Process Strength

Acetylene Chemistry

Low temperature in liquid Ammonia

Acetylation

Acetic Anhydride / Acetic Acid

Azidation

Sodium Azide

Bromination

Bromine, Brominating Agent & Catalyst.

Chloro Sulphonation

Chloro Sulfonic Acid, Oleum at various temperature

Chlorination

With Reagents SO2Cl2, PCl3, PCl5, Chlorine with AlCl3

Cyclisation

With Light Paraffin Oil at 250oC

Cyano Ethylation

With Acetonitrile at around 100oC

Cyanation

Sodium Cyanide / HCN

Claisen Condensation

On Benzaldehyde

Diazotization

NaNO2 / Nitrosyl Sulphuric Acid / Isobutyl Nitrile.

Dicarboxylation

Dilute Caustic at High Temperature and Pressure.

Ethoxylation

Ethylene Oxide at temperature 40 to 100 Deg C

Ethylation

Bromide with Diethyl Sulphate.

Methylation Methyl Chloride; Bromide with Dimethyl Sulphate
Chloromethylation Bromide with Chloromethylation Compounds

Fractionation

Separation of various Isomers at wide temperature range.

Formylation

POCl3 and DMF

Grignard

With Magnesium Compounds

Hydrolysis

Caustic High Pressure

Lithiation

N-Butyl Lithium/ Lithium-di-isopropylamide / Lithium Metal

Nitration

Fuming HNO3, NaNO2 as well as HNO3 in Acetic Acid and Sulfuric Acid.

Oxidation

Hydrogen Peroxide/ Potassium Permanganese , Nitric Acid/ Sulphuric Acid.

PhoSgenation

Phosgene, Methyl Chloro Formate & Ethyl Chloroformate.

Resolution

R-(+)-PEA, D-Camphor Sulphonic Aicd, S-(+)-PEA

Reduction

Acidic with Fe & Zn Alkaline with Catalytic Catalytic Hydrogenation.

Stereo Specific Reaction

Sodium Borohydride. MDEB, Vitride.

Specialised condensation Reaction

STBO/ KTB/Sodium Ethoxide/ Sodium Metal.

Thio Alkylation

Mercaptide Solutions.

Thiolation

Hypexanthine / CS2

 

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